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12R-LOX and eLOX-3 are engaged in the synthesis of the cornified envelope (CE) through the enzymatic synthesis of lipid oxide products in the epidermis to maintain the skin barrier and reduce transepidermal water loss (TEWL) (Krieg and Furstenberger, 2014)
Many researchers have tried to link n-3 PUFA to the prevention of SUDEP via the reduction of cardiac arrhythmias [114,115,116,117]